Basic Information

Gene symbol ROR1 Synonyms NTRKR1, dJ537F10.1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description receptor tyrosine kinase like orphan receptor 1

GTO ID GTC3317
Trial ID NCT05694364
Disease Diffuse Large B-Cell Lymphoma | Acute Lymphoblastic Leukemia | Mantle Cell Lymphoma | Triple-Receptor Negative Breast Cancer | Chronic Lymphocytic Leukemia
Altered gene ROR1
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment PRGN-3007
PhasePhase1
Recruitment statusRecruiting
TitleDose Escalation/Dose Expansion Study of PRGN-3007 UltraCAR-T Cells in Patients With Advanced Hematologic and Solid Tumor Malignancies
Year2023
CountryUnited States
Company sponsorH. Lee Moffitt Cancer Center and Research Institute
Other ID(s)MCC-21622|PRGN-3007
Vector information
VectorSleeping Beauty system
Additional featurembIL15, HER1t

Clinical Result

Cohort 1
Administration route None
Dosage 1E6 cells/kg, 3E6 cells/kg, 1E7 cells/kg
Donor type Autologous
Pts 88
Age Adult, Older_Adult

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