Basic Information




Gene symbol tk


GTO ID GTC3311
Trial ID NCT05686798
Disease Malignant Astrocytoma
Altered gene E1|E3|yCD|tk|ADP
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment AdV5-yCD/mutTKSR39rep-AdVP
PhasePhase1
Recruitment statusRecruiting
TitlePhase I Study of Replication-Competent Adenovirus-Mediated Double Suicide Gene Therapy With Stereotactic Radiosurgery in Patients With Recurrent or Progressive High Grade Astrocytomas
Year2022
CountryUnited States
Company sponsorHenry Ford Health System
Other ID(s)HFHS-21-02
Vector information
Vectoradenovirus
ConstructAd5-yCD/mutTKSR39rep-ADP
Vector typesecond-generation adenovirus
Transgene/Inserted geneyCD; HSV-TK; ADP
Viral genome modificationAd5-yCD/mutTKSR39rep-ADP contains a yeast cytosine deaminase (yCD)/mutantSR39 herpes simplex virus thymidine kinase (mutTKSR39) fusion gene in the E1 region as well as the Ad5 adenoviral death protein (ADP) gene in the E3 region.

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage 1E11~1E12 vp
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph