Basic Information


Gene symbol GH1 Synonyms GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B, IGHD2, hGH-N Type of gene protein-coding
Description growth hormone 1

Gene symbol LIPF Synonyms GL, HGL, HLAL Type of gene protein-coding
Description lipase F, gastric type

Gene symbol UL128 Synonyms None Type of gene protein-coding
Description contains signal peptide; similar to CC chemokines; complexed with envelope glycoproteins H and L; essential in non-fibroblast cells; involved in cell entry

Gene symbol UL130 Synonyms None Type of gene protein-coding
Description envelope glycoprotein UL130

Gene symbol UL131A Synonyms None Type of gene protein-coding
Description envelope protein UL131A

GTO ID GTC3307
Trial ID NCT05683457
Disease Human Cytomegalovirus Infection
Altered gene gB|gH|gL|UL128|UL130|UL131A
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment mRNA-1647
PhasePhase2
Recruitment statusRecruiting
TitleA Phase 2, Observer-Blind, Placebo-Controlled Proof-of-Concept Trial to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus Vaccine in Patients Who Have Undergone Allogeneic Hematopoietic Cell Transplantation (HCT)
Year2023
CountryUnited States
Company sponsorModernaTX, Inc.
Other ID(s)mRNA-1647-P205
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort1: mRNA-1647
Administration route intramuscular injection
Dosage mRNA-1647, Day 42, Day 67, and Day 92, and a booster dose on Day 180
Age Adult, Older_Adult
Cohort2: Placebo
Administration route intramuscular injection
Dosage Placebo, Day 42, Day 67, and Day 92, and a booster dose on Day 180
Age Adult, Older_Adult

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