Basic Information

Gene symbol APOC3 Synonyms APOCIII, Apo-C3, ApoC-3 Type of gene protein-coding
Description apolipoprotein C3

GTO ID GTC3306
Trial ID NCT05681351
Disease Severe Hypertriglyceridemia
Altered gene APOC3
Therapeutic/Target gene Target gene
TherapyASO
Treatment Olezarsen|ISIS 678354|IONIS-APOCIII-LRx|AKCEA-APOCIII-LRx
Co-treatment Clopidogrel
PhasePhase3
Recruitment statusRecruiting
TitleAn Open-Label Extension Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia (SHTG)
Year2022
CountryAustralia|Bulgaria|Canada|Czechia|Denmark|France|Hungary|Israel|Italy|Netherlands|New Zealand|Norway|Poland|Slovakia|South Africa|Spain|Sweden|Turkey|United Kingdom|United States
Company sponsorIonis Pharmaceuticals, Inc.
Other ID(s)ISIS 678354-CS15|2022-501999-26-00
Vector information
VectorGalNAc3

Clinical Result

Cohort 1
Administration route subcutaneous injection
Dosage Olezarsen, once every 4 weeks from Week 1 through Week 49
Pts 700
Age Adult, Older_Adult

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