Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC3296
Trial ID NCT05672173
Disease Chronic Lymphocytic Leukemia | Richter Syndrome
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Breyanzi|Lisocabtagene maraleucel|liso-cel|JCAR017
Location approved US, Japan, EU, Switzerland, UK, Canada
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleLisocabtagene Maraleucel, Nivolumab and Ibrutinib for the Treatment of Richter's Transformation
Year2023
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)22040|NCI-2022-10247|22040|P30CA033572
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneanti‐CD19 single‐chain variable fragment; 4‐1BB costimulatory motif; CD3ζ T‐cell activation domain
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 20
Age Adult, Older_Adult

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