Basic Information

Gene symbol CD33 Synonyms CD33rSiglec, SIGLEC-3, SIGLEC3, p67 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description CD33 molecule

GTO ID GTC3295
Trial ID NCT05672147
Disease Acute Myeloid Leukemia
Altered gene CD33
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD33 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleCD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia
Year2023
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)21665|NCI-2022-10310|21665|P30CA033572
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Allogeneic
Pts 27
Age Adult, Older_Adult
Lymph depletion Yes

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