Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD70 Synonyms CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A Type of gene protein-coding
Description CD70 molecule

GTO ID GTC3290
Trial ID NCT05667155
Disease B-Cell Non-Hodgkin's Lymphoma
Altered gene CD19|CD70
Therapeutic/Target gene Target gene
TherapyCAR-NK cell
Treatment CD19/70 CAR-NK cells
PhasePhase1
Recruitment statusRecruiting
TitleClinical Study of Cord Blood-derived CAR NK Cells Targeting CD19/CD70 in Refractory/Relapsed B-cell Non-Hodgkin Lymphoma
Year2022
CountryChina
Company sponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Other ID(s)2022-088
Vector information
Vectorlentivirus
Additional featureIL15

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2E6 cells/kg, 4E6 cells/kg, 8E6 cells/kg
Pts 48
Age Adult, Older_Adult
Lymph depletion Yes

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