Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC3274
Trial ID NCT05651178
Disease Central Nervous System Lymphoma
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleHuman CD19-CD22 Targeted T Cells Injection for Refractory/Relapsed Central Nervous System Leukemia/Lymphoma Patients
Year2022
CountryChina
Company sponsorHrain Biotechnology Co., Ltd.
Other ID(s)HRAIN02-CNSL01

Clinical Result

Cohort 1
Administration route None
Dosage 1E6 cells/kg, 3E6 cells/kg, 5E6 cells/kg, single infusion
Donor type Autologous
Pts 20
Age Adult, Older_Adult
Lymph depletion Yes

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