Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC3269
Trial ID NCT05648019
Disease Childhood B-Cell Acute Lymphoblastic Leukemia | B-Cell Acute Lymphoblastic Leukemia | Acute Lymphoblastic Leukemia | Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleCD19-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory B-Lineage Leukaemia / Lymphoma - A Feasibility Protocol
Year2022
CountrySingapore
Company sponsorKK Women's and Children's Hospital
Other ID(s)SHCELL18P1
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 0.2~5E6 cells/kg
Pts 40
Age Child, Adult, Older_Adult

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