Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC3263
Trial ID NCT05641428
Disease B-Cell Non-Hodgkin's Lymphoma | Diffuse Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment ARI-0001|Axi-cel|YesCAR-Ta|Axicabtagene Ciloleucel
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleComparison of Point-of-care Produced CAR T-cell With Commercial CAR T-cells in Patients With R/R LBCL
Year2022
CountryNetherlands
Company sponsorUniversity Medical Center Groningen
Other ID(s)HO161|2021-000937-15
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ|scFv-CD28-CD3ζ

Clinical Result

Cohort1: ARI-0001
Administration route None
Dosage 2E6 cells/kg
Pts 300
Age Adult, Older_Adult
Cohort2: Axi-cel
Administration route intravenous infusion
Dosage 2E6 cells/kg
Age Adult, Older_Adult

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