Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC3256
Trial ID NCT05633615
Disease Primary Mediastinal B-Cell Lymphoma | Follicular Lymphoma | Diffuse Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Co-treatment mosunetuzumab/polatuzumab
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleTesting Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
Year2022
CountryUnited States
Company sponsorSWOG Cancer Research Network
Other ID(s)S2114|NCI-2022-07930|S2114|S2114|U10CA180888
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 396
Age Adult, Older_Adult
Lymph depletion Yes

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