Basic Information

Gene symbol EPHA2 Synonyms ARCC2, CTPA, CTPP1, CTRCT6, ECK Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description EPH receptor A2

Gene symbol KRAS Synonyms C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, KI-RAS, KRAS1, KRAS2, NS, NS3, OES, RALD, RASK2, c-Ki-ras, c-Ki-ras2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description KRAS proto-oncogene, GTPase

GTO ID GTC3253
Trial ID NCT05631899
Disease Solid Tumor
Altered gene KRAS|EPHA2
Therapeutic/Target gene Target gene
TherapyCAR-DC cell
Treatment KRAS-EphA-2-CAR-DC
Co-treatment anti-PD-1 antibody+anti-CTLA4 antibody
PhasePhase1
Recruitment statusRecruiting
TitleCombination of CAR-DC Vaccine and Anti-PD-1 Antibody in Local Advanced/Metastatic Solid Tumors
Year2022
CountryChina
Company sponsorChinese PLA General Hospital
Other ID(s)CHN-PLAGH-BT-074

Clinical Result

Cohort1: anti-PD-1 antibody+anti-CTLA4 antibody
Administration route intravenous infusion
Dosage 5~10E6 cells/dose
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: anti-PD-1 antibody
Administration route intravenous infusion
Dosage 5~10E6 cells/dose
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes

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