Basic Information


GTO ID GTC3244
Trial ID NCT05623488
Disease Breast Cancer
Altered gene MESO
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment huCAR-T-meso cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleCAR T Cells in Mesothelin-Expressing Breast Cancer
Year2022
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC# 15122, IRB # 852205
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage 30E7 cells, 30E6 cells
Donor type Autologous
Pts 12
Age Adult, Older_Adult

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