Basic Information

Gene symbol PPP1R1A Synonyms I1, IPP1 Type of gene protein-coding
Description protein phosphatase 1 regulatory inhibitor subunit 1A

GTO ID GTC3219
Trial ID NCT05598333
Disease Congestive Heart Failure | Non-Ischemic Cardiomyopathy
Altered gene PPP1R1A
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AB-1002|NAN-101
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleA Phase 2, Adaptive, Double-blinded, Placebo Controlled, Randomized, Multi-center Trial to Evaluate the Efficacy, Safety and Tolerability of Intracoronary Infusion of AB-1002 in Adult Subjects With New York Heart Association (NYHA) Class III Heart Failure and Non-ischemic Cardiomyopathy
Year2022
CountryUnited States
Company sponsorAsklepios Biopharmaceutical, Inc.
Other ID(s)ASK-CHF2-CS201

Clinical Result

Cohort1: dose level 1
Administration route intracoronary injection
Dosage 3.25E13 vg
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route intracoronary injection
Dosage 6.5E13 vg
Age Adult, Older_Adult

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