Basic Information

Gene symbol PROM1 Synonyms AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description prominin 1

Gene symbol CD44 Synonyms CDW44, CSPG8, ECM-III, ECMR-III, H-CAM, HCELL, HUTCH-1, HUTCH-I, Hermes-1, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD44 molecule (IN blood group)

GTO ID GTC3206
Trial ID NCT05577091
Disease Glioblastoma
Altered gene CD44|CD133
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Tris CAR-T cells
Generation4th
PhasePhase1
Recruitment statusNot Recruiting
TitleTris-CAR-T Cell Therapy for Recurrent Glioblastoma
Year2022
CountryChina
Company sponsorBeijing Tiantan Hospital
Other ID(s)TTSW2021-01

Clinical Result

Cohort1: dose level 1
Administration route None
Dosage 1E7 cells, 1~6 doses
Donor type Autologous
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route None
Dosage 1E8 cells, 5E6cells, 1~6 dose
Donor type Autologous
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route None
Dosage 5E7 cells, weekly administered, maximum 8 weeks
Donor type Autologous
Age Adult, Older_Adult

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