Basic Information


Gene symbol GH1 Synonyms GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B, IGHD2, hGH-N Type of gene protein-coding
Description growth hormone 1

Gene symbol LIPF Synonyms GL, HGL, HLAL Type of gene protein-coding
Description lipase F, gastric type

Gene symbol UL128 Synonyms None Type of gene protein-coding
Description contains signal peptide; similar to CC chemokines; complexed with envelope glycoproteins H and L; essential in non-fibroblast cells; involved in cell entry

Gene symbol UL130 Synonyms None Type of gene protein-coding
Description envelope glycoprotein UL130

Gene symbol UL131A Synonyms None Type of gene protein-coding
Description envelope protein UL131A

GTO ID GTC3203
Trial ID NCT05575492
Disease Human Cytomegalovirus Infection
Altered gene gB|gH|gL|UL128|UL130|UL131A
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment mRNA-1647
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleA Phase 1/2a Open-Label Dose-Ranging and Observer-Blind Placebo-Controlled, Safety and Immunogenicity Study of mRNA-1647 Cytomegalovirus Vaccine in Female and Male Participants 9 to 15 Years of Age and Participants 16 to 25 Years of Age
Year2022
CountryCanada|United Kingdom|United States
Company sponsorModernaTX, Inc.
Other ID(s)mRNA-1647-P104|2022-001545-20
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort1: participants 9 to 15 years of age_mRNA-1647
Administration route intramuscular injection
Dosage mRNA-1647, Dose Level A, B, Day 1, Month 2, and Month 6
Age Child, Adult
Cohort2: participants 9 to 15 years of age and 16 to 25 years of age_mRNA-1647
Administration route intramuscular injection
Dosage mRNA-1647, Dose Level C, Day 1, Month 2, and Month 6
Age Child, Adult
Cohort3: Placebo
Administration route intramuscular injection
Dosage placebo, Day 1, Month 2, and Month 6
Age Child, Adult

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