Basic Information

Gene symbol APOC3 Synonyms APOCIII, Apo-C3, ApoC-3 Type of gene protein-coding
Description apolipoprotein C3

GTO ID GTC3189
Trial ID NCT05552326
Disease Severe Hypertriglyceridemia
Altered gene APOC3
Therapeutic/Target gene Target gene
TherapyASO
Treatment Olezarsen|ISIS 678354|IONIS-APOCIII-LRx|AKCEA-APOCIII-LRx
Co-treatment Clopidogrel
PhasePhase3
Recruitment statusActive, Not Recruiting
TitleA Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia
Year2022
CountryArgentina|Belgium|Brazil|Bulgaria|Canada|Czechia|France|Greece|Hungary|India|Italy|Lithuania|Malaysia|Mexico|Netherlands|Poland|Portugal|Romania|Slovakia|Spain|Sweden|China|United States
Company sponsorIonis Pharmaceuticals, Inc.
Other ID(s)ISIS 678354-CS6|2022-501420-20
Vector information
VectorGalNAc3

Clinical Result

Cohort1: Olezarsen
Administration route subcutaneous injection
Dosage Olezarsen, once every 4 weeks, from Week 1 through Week 49
Age Adult, Older_Adult
Cohort2: Placebo
Administration route subcutaneous injection
Age Adult, Older_Adult

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