Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

Gene symbol tat Synonyms None Type of gene protein-coding
Description Tat

Gene symbol vif Synonyms None Type of gene protein-coding
Description Vif

GTO ID GTC3183
Trial ID NCT05540964
Disease HIV Infection
Altered gene CCR5|tat|vif
Therapeutic/Target gene Target gene
TherapyGene transfer
Treatment AGT103-T
Recruitment statusEnrolling By Invitation
TitleAn Antiretroviral Treatment Interruption(ATI) Study to Evaluate the Impact and Durability of AGT103-T to Suppress Human Immunodeficiency Virus Replication in the Absence of Antiretroviral Therapy(ART) in Participants With Human Immunodeficiency Virus(HIV) Previously Treated With AGT103-T
Year2022
CountryUnited States
Company sponsorAmerican Gene Technologies International Inc.
Other ID(s)AGT-HC-169
Vector information
Vectorlentivirus
Vector typethe third generation, self-inactivating lentivirus vector
Transgene/Inserted geneA cluster of three engineered microRNAs (miRNAs) designed to decrease RNA levels through the recognition of target sequences in mRNA encoding the host protein CCR5, as well as in genomic or sub-genomic RNA sequences from the HIV Tat and Vif genes.
Regulatory elementEF1α promoter; a Woodchuck hepatitis virus post-transcriptional regulatory element (WPRE)

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 7
Age Adult, Older_Adult
References PMID: 36452901

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