Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

Gene symbol tat Synonyms None Type of gene protein-coding
Description Tat

Gene symbol vif Synonyms None Type of gene protein-coding
Description Vif

GTO ID GTC3172
Trial ID NCT05529342
Disease HIV Infection
Altered gene CCR5|tat|vif
Therapeutic/Target gene Target gene
TherapyGene transfer
Treatment AGT103-T
Recruitment statusEnrolling By Invitation
TitleA Long-Term Follow-Up Study of Participants Treated With the Lentiviral-Based Genetically Modified, Autologous Cell Product, AGT103-T
Year2022
CountryUnited States
Company sponsorAmerican Gene Technologies International Inc.
Other ID(s)AGT103-T-LTFU
Vector information
Vectorlentivirus
Vector typethe third generation, self-inactivating lentivirus vector
Transgene/Inserted geneA cluster of three engineered microRNAs (miRNAs) designed to decrease RNA levels through the recognition of target sequences in mRNA encoding the host protein CCR5, as well as in genomic or sub-genomic RNA sequences from the HIV Tat and Vif genes.
Regulatory elementEF1α promoter; a Woodchuck hepatitis virus post-transcriptional regulatory element (WPRE)

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 7
Age Adult, Older_Adult
References PMID: 36452901

Relationship Graph

Overview of Knowledge Graph