Basic Information

Gene symbol KRT31 Synonyms HA1, Ha-1, KRTHA1, hHa1 Type of gene protein-coding
Description keratin 31

Gene symbol KRT32 Synonyms HA2, HKA2, KRTHA2, hHa2 Type of gene protein-coding
Description keratin 32

GTO ID GTC3131
Trial ID NCT05473910
Disease Myelodysplastic Syndrome | Leukemia
Altered gene HA1|HA2
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment TSC-100|TSC-101
HLAHLA-A*02:01
PhasePhase1
Recruitment statusRecruiting
TitleA Controlled Multi-Arm Ph1 Study Evaluating the Safety and Feasibility of TCR Engineered Donor TCells Targeting HA1 (TSC-100) or HA2 (TSC-101) in HLA-A0201 Positive Patients Undergoing Haploidentical Allogeneic Stem Cell Transplantation
Year2022
CountryUnited States
Company sponsorTScan Therapeutics, Inc.
Other ID(s)TSCAN-001

Clinical Result

Cohort1: HA-1 positive
Administration route infusion
Donor type Allogeneic
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: HA-2 positive
Administration route infusion
Donor type Allogeneic
Age Adult, Older_Adult
Lymph depletion Yes

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