Basic Information

Gene symbol NKX3-2 Synonyms BAPX1, NKX3.2, NKX3B, SMMD Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description NK3 homeobox 2

GTO ID GTC3110
Trial ID NCT05454566
Disease Knee Osteoarthritis
Altered gene NKX3-2
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment ICM-203
PhasePhase1|Phase2
Recruitment statusNot Recruiting
TitleA Single Dose Escalation Study of Intra-Articular ICM-203 in Subjects With Kellgren-Lawrence Grade 2 or Grade 3 Osteoarthritis of the Knee
Year2022
CountryRepublic of Korea
Company sponsorICM Co. Ltd.
Other ID(s)ICM 20-1003
Vector information
Vectoradeno-associated virus
ConstructrAAV-hNkx3.2
Vector typerecombinant adeno-associated virus (rAAV) vector
Transgene/Inserted genea truncated form of human Nkx3.2

Clinical Result

Cohort1: dose level 1
Administration route intraarticular injection
Dosage 6E12 vg
Pts 6
Age Adult, Older_Adult
References DOI: 10.1016/j.ostima.2024.100189
Cohort2: dose level 2
Administration route intraarticular injection
Dosage 2E13 vg
Pts 6
Age Adult, Older_Adult
References DOI: 10.1016/j.ostima.2024.100189
Cohort3: dose level 3
Administration route intraarticular injection
Dosage 6E13 vg
Pts 6
Age Adult, Older_Adult
References DOI: 10.1016/j.ostima.2024.100189

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