Basic Information

Gene symbol MSLN Synonyms MPF, SMRP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description mesothelin

GTO ID GTC3108
Trial ID NCT05451849
Disease Lung Non-Small Cell Carcinoma | Colorectal Carcinoma | Peritoneal Mesothelioma | Mesothelioma | Triple-Receptor Negative Breast Cancer | Malignant Mesothelioma | Ovarian Cancer | Ovarian Melanoma | Pancreatic Cancer | Ovarian Serous Cystadenocarcinoma | Pancreatic Adenocarcinoma | Colorectal Cancer | Cholangiocarcinoma | Mesotheliomas Pleural
Altered gene MSLN
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment TC-510|MSLN TCR-T cells
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleA Phase 1/2 Single Arm Open-Label Clinical Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer
Year2022
CountryUnited States
Company sponsorTCR2 Therapeutics
Other ID(s)TCR2-21-01

Clinical Result

Cohort 1
Administration route None
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes

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