Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol GPRC5D Synonyms None Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description G protein-coupled receptor class C group 5 member D

GTO ID GTC3084
Trial ID NCT05431608
Disease Multiple Myeloma
Altered gene BCMA|GPRC5D
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MCARH125;MCARH109
PhasePhase1
Recruitment statusRecruiting
TitleA Study of MCARH109 and MCARH125 in People With Multiple Myeloma
Year2022
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)22-052

Clinical Result

Cohort1: dose level 1
Administration route None
Dosage MCARH125: 5E7 cells, MCARH109: 5E7 cells
Pts 3~6
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route None
Dosage MCARH125: 5E7 cells, MCARH109: 0 cells
Pts 3~6
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route None
Dosage MCARH125: 1.5E8 cells, MCARH109: 0 cells
Pts 3~6
Age Adult, Older_Adult
Cohort4: dose level 4
Administration route None
Dosage MCARH125: 1.5E8 cells, MCARH109: 5E7 cells
Pts 3~6
Age Adult, Older_Adult
Cohort5: dose level 5
Administration route None
Dosage MCARH125: 1.5E8 cells, MCARH109: 1.5E8 cells
Pts 3~6
Age Adult, Older_Adult

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