Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC3072
Trial ID NCT05418088
Disease Chronic Lymphocytic Leukemia | Acute Lymphoblastic Leukemia | B-Cell Lymphoma | B-Cell Prolymphocytic Leukemia | B-Cell Acute Lymphoblastic Leukemia | Non-Hodgkin's Lymphoma
Altered gene CD19|CD20|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD20/CD22 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleGenetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies
Year2022
CountryUnited States
Company sponsorSumithira Vasu
Other ID(s)OSU-21170|NCI-2022-02972

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 36
Age Adult, Older_Adult
Lymph depletion Yes

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