Basic Information


GTO ID GTC3070
Trial ID NCT05417126
Disease Stargardt Disease
Altered gene MCO
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment vMCO-010
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleA Phase 2a, Open Label Multicenter Clinical Trial to Evaluate the Safety and Effects of a Single Intravitreal Injection of vMCO-010 Optogenetic Therapy in Subjects With Stargardt Disease
Year2022
CountryUnited States
Company sponsorNanoscope Therapeutics Inc.
Other ID(s)NTXMCO-004
Vector information
Vectoradeno-associated virus
ConstructAAV2-MCO
Vector typeadeno-associated virus serotype 2 (AAV2) vector
Transgene/Inserted genemulti-characteristic opsin (MCO) gene

Clinical Result

Cohort 1
Administration route intravitreal injection
Dosage 1.2E11 gc/eye
Age Child, Adult, Older_Adult
References : MCO-010 intravitreal optogenetic therapy in Stargardt disease. 6-month outcomes from the Phase 2 STARLIGHT trial

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