Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC3008
Trial ID NCT05347485
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Carvykti|Ciltacabtagene Autoleucel|Cilta-cel|JNJ-68284528
Location approved US, EU, UK, Japan, Australia, Canada
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleA Study of JNJ-68284528 Out-of-Specification (OOS) for Commercial Release in Participants With Multiple Myeloma
Year2022
CountryUnited States
Company sponsorJanssen Scientific Affairs, LLC
Other ID(s)CR109014|68284528MMY2005
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E6 cells/kg
Donor type Autologous
Pts 330
Age Adult, Older_Adult
Lymph depletion Yes

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