Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC2944
Trial ID NCT05257083
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Carvykti|Ciltacabtagene Autoleucel|Cilta-cel|JNJ-68284528
Co-treatment Daratumumab, Bortezomib, Lenalidomide, Dexamethasone
Location approved US, EU, UK, Japan, Australia, Canada
Generation2nd
PhasePhase3
Recruitment statusNot Recruiting
TitleA Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma
Year2022
CountrySwitzerland
Company sponsorEuropean Myeloma Network
Other ID(s)EMN28/68284528MMY3005|2021-003284-10
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 750
Age Adult, Older_Adult
Lymph depletion Yes

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