Basic Information

Gene symbol VEGFC Synonyms Flt4-L, LMPH1D, LMPHM4, VRP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor C

GTO ID GTC2896
Trial ID NCT05197270
Disease Age-Related Macular Degeneration
Altered gene VEGFC
Therapeutic/Target gene Target gene|Therapeutic gene
TherapymiRNA|mRNA
Treatment 4D-150
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleA Phase 1/2 Dose-Escalation and Randomized, Controlled, Masked Expansion Trial of Intravitreal 4D-150 Gene Therapy in Adults With Neovascular (Wet) Age-Related Macular Degeneration
Year2021
CountryUnited States|Puerto Rico
Company sponsor4D Molecular Therapeutics
Other ID(s)4D-150-C001
Vector information
Vectoradeno-associated virus
Transgene/Inserted geneVEGF-C miRNA; codon-optimized sequence encoding aflibercept

Clinical Result

Cohort1: 4D-150
Administration route intravitreal injection
Dosage 4D-150, single dose, Day 1
Age Adult, Older_Adult
References 38927656|DOI: 10.1101/2021.06.24.449775 | Invest. Ophthalmol. Vis. Sci. 2023;64(8):5055.
Cohort2: Aflibercept
Administration route intravitreal injection
Age Adult, Older_Adult
References 38927656|DOI: 10.1101/2021.06.24.449775 | Invest. Ophthalmol. Vis. Sci. 2023;64(8):5055.

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