Basic Information

Gene symbol MSLN Synonyms MPF, SMRP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description mesothelin

GTO ID GTC2877
Trial ID NCT05166070
Disease Solid Tumor
Altered gene MSLN
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment RD133
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleAn Exploratory Clinical Study of RD133 in Subjects With Relapsed or Refractory MSLN-Positive Solid Tumors
Year2021
CountryChina
Company sponsorThe First Affiliated Hospital with Nanjing Medical University
Other ID(s)RD133CI002
Vector information
Vectorlentivirus
Additional featuretEGFR

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E6 cells/kg, 3E6 cells/kg, 6E6 cells/kg
Pts 24
Age Adult, Older_Adult
Lymph depletion Yes

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