Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2834
Trial ID NCT05105867
Disease B-Cell Non-Hodgkin's Lymphoma | B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleCD19 Targeted Universal Chimeric Antigen Receptor T Cells Injection for CD19+ Refractory/Relapsed B-cell Malignancies
Year2021
CountryChina
Company sponsor920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
Other ID(s)GC011-411

Clinical Result

Cohort 1
Administration route intravenous infusion
Pts 4
Age Adult, Older_Adult
Outcome 3/4(MRD-CR/CRi); 1/4(PR)
Adverse reactions Cytokine release syndrome (CRS) presented as Grade 2 and Grade 3 with no Grade 4 or 5 events. No immune effector cell-associated neurotoxicity syndrome (ICANS) or acute graft-versus-host disease (aGvHD) were observed.
References : Gracell Biotechnologies to Present Data at AACR Annual Meeting 2022 Showcasing Early First-in-Human Results for GC502 in r/r B-ALL

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