Basic Information

Gene symbol GPC3 Synonyms DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 Type of gene protein-coding
Description glypican 3

GTO ID GTC2831
Trial ID NCT05103631
Disease Solid Tumor | Embryonal Sarcoma | Liposarcoma | Yolk Sac Tumor | Malignant Rhabdoid Tumor | Liver Carcinoma | Rhabdomyosarcoma
Altered gene GPC3
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CATCH T cells
PhasePhase1
Recruitment statusRecruiting
TitleInterleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Hepatocellular Carcinoma
Year2021
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-49796 CATCH
Vector information
Vectorretrovirus
Transgene/Inserted geneiCasp9 Suicide Gene
Additional featureIL15

Clinical Result

Cohort 1
Administration route None
Dosage 3E7 cells/m^2, 1E8 cells/m^2, 3E8 cells/m^2, 1E9 cells/m^2
Donor type Autologous
Pts 27
Age Adult, Older_Adult

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