Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2825
Trial ID NCT05094206
Disease B-Cell Chronic Lymphocytic Leukemia | B-Cell Non-Hodgkin's Lymphoma
Altered gene CD19|CD20|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD20/CD22 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleCAR20.19.22 T-cells in Relapsed, Refractory B-cell Malignancies
Year2021
CountryUnited States
Company sponsorMedical College of Wisconsin
Other ID(s)PRO00041528

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 0.75E6 cells/kg, 1E6 cells/kg, 2.5E6 cells/kg, 5E6 cells/kg
Pts 48
Age Adult, Older_Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph