Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2811
Trial ID NCT05077527
Disease Non-Hodgkin's Lymphoma | Follicular Lymphoma | B-Cell Lymphoma | Primary Mediastinal B-Cell Lymphoma | Diffuse Large B-Cell Lymphoma | Relapsed/Refractory Diffuse Large B-Cell Lymphoma | HIV Infection
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Generation2nd
PhasePhase1
Recruitment statusNot Recruiting
TitleImmune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
Year2021
CountryUnited States
Company sponsorAIDS Malignancy Consortium
Other ID(s)AMC-112|NCI-2021-02771|AMC-112|AMC-112|UM1CA121947
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 20
Age Adult, Older_Adult
Lymph depletion Yes

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