Basic Information

Gene symbol S Synonyms E2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description spike glycoprotein

GTO ID GTC2809
Trial ID NCT05074368
Disease COVID-19
Altered gene S
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment mRNA-1273|Elasomeran|Spikevax
Co-treatment ChAdOx1-nCov-19
Location approved UK, Canada, Taiwan, Switzerland, Japan, EU, Australia, South Korea, Singapore, US
PhaseNot Applicable
Recruitment statusCompleted
TitleComparative Analysis of Neutralizing Antibody Response Among Heterologous ChAdOx1-nCov-19/mRNA-1273 Vaccination and Homologous ChAdOx1-nCov-19 or Homologous mRNA-1273 Vaccination
Year2021
CountryChina
Company sponsorNational Taiwan University Hospital
Other ID(s)202106039MINA
Vector information
Vectoradenovirus|lipid nanoparticle

Clinical Result

Cohort1: ChAdOx1-nCov-19
Administration route None
Dosage Astra-Zeneca vaccine, 0.5 mL/dose
Pts 499
Age Adult, Older_Adult
References PMID: 35305895
Cohort2: ChAdOx1-nCov-19_mRNA-1273_8 weeks apart
Administration route None
Dosage Moderna COVID-19 Vaccine, 0.5 mL/dose; Astra-Zeneca vaccine, 0.5 mL/dose
Pts 100
Age Adult, Older_Adult
References PMID: 35305895
Cohort3: ChAdOx1-nCov-19_mRNA-1273_4 weeks apart
Administration route None
Dosage Moderna COVID-19 Vaccine, 0.5 mL/dose; Astra-Zeneca vaccine, 0.5 mL/dose
Pts 100
Age Adult, Older_Adult
References PMID: 35305895
Cohort4: mRNA-1273
Administration route None
Dosage Moderna COVID-19 Vaccine 0.5, mL/dose
Pts 100
Age Adult, Older_Adult
References PMID: 35305895
Cohort5: ChAdOx1-nCov-19_mRNA-1273_12 weeks apart
Administration route None
Dosage Moderna COVID-19 Vaccine, 0.5 mL/dose; Astra-Zeneca vaccine, 0.5 mL/dose
Pts 99
Age Adult, Older_Adult
References PMID: 35305895

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