Basic Information

Gene symbol S Synonyms E2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description spike glycoprotein

GTO ID GTC2804
Trial ID NCT05067933
Disease COVID-19
Altered gene S
Therapeutic/Target gene Therapeutic gene
TherapydsRNA
Treatment VXA-CoV2-1.1-S
PhasePhase2
Recruitment statusCompleted
TitleA Phase 2, Double-Blind, Multi-Center, Randomized, Placebo-Controlled, Dose-Ranging Trial to Determine the Safety, Immunogenicity and Efficacy of an Adenoviral-Vector Based Vaccine Expressing Severe Acute Respiratory Syndrome (SARS-CoV-2) and dsRNA Adjuvant Administered Orally
Year2021
CountryUnited States
Company sponsorVaxart
Other ID(s)VXA-COV2-201
Vector information
Vectoradenovirus
Transgene/Inserted geneThe SARS-CoV-2 stabilized S protein coding sequences; dsRNA adjuvant
Viral genome modificationThe E1 and partial E3 regions of the parental adenovirus DNA are deleted.

Clinical Result

Cohort1: Naïve_VXA-CoV2-1.1-S_dose level 1_young adult
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E10 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort2: Naïve_VXA-CoV2-1.1-S_dose level 2_young adult
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E11 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort3: Naïve_VXA-CoV2-1.1-S_dose level 1_older adult
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E10 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort4: Naïve_VXA-CoV2-1.1-S_dose level 2_older adult
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E11 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort5: Prior vaccinated_VXA-CoV2-1.1-S_dose level 1_young adult
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E10 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort6: Prior vaccinated_VXA-CoV2-1.1-S_dose level 2_young adult
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E11 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort7: Prior vaccinated_VXA-CoV2-1.1-S_dose level 1_older adult
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E10 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort8: Prior vaccinated_VXA-CoV2-1.1-S_dose level 2_older adult
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E11 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort9: Active vaccine
Administration route oral
Dosage VXA-CoV2-1.1-S, 1E10 repeat-dose, Days 1 and 29
Age Adult, Older_Adult
Cohort10: Placebo
Administration route oral
Age Adult, Older_Adult

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