Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2785
Trial ID NCT05037669
Disease Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment PACE CAR-T19
Generation2nd
PhasePhase1
Recruitment statusWithdrawn
TitleProgrammed Allogeneic CRISPR-edited T Cells Engineered to Express Anti-CD19 Chimeric Antigen Receptor (PACE CART19) in Patients With Relapsed Or Refractory CD19+ Leukemia and Lymphoma
Year2021
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 27419
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Additional featureCRISPR/Cas9 RNA system

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Allogeneic
Pts 0
Age Adult, Older_Adult

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