Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2758
Trial ID NCT05010564
Disease B-Cell Leukemia
Altered gene CD19|CD20|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment TRICAR-ALL
Generation2nd
PhasePhase1
Recruitment statusNot Recruiting
TitleTrivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL)
Year2021
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-49235 TRICAR-ALL
Vector information
Vectorretrovirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 3E6 cells/m^2, 1E7 cells/m^2, 3E7 cells/m^2, 1E8 cells/m^2
Donor type Autologous
Pts 38
Age Child, Adult
Lymph depletion Yes

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