Basic Information

Gene symbol ACE2 Synonyms ACEH Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description angiotensin converting enzyme 2

Gene symbol PDCD1 Synonyms CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description programmed cell death 1

GTO ID GTC2743
Trial ID NCT04990557
Disease COVID-19 Respiratory Infection
Altered gene PDCD1|ACE2
Therapeutic/Target gene Target gene
TherapyGene editing
Treatment PD-1/ACE2 Knockout T cells
PhasePhase1|Phase2
Recruitment statusUnknown
TitleCRISPR/Cas9-modified Human T Cell ( PD-1and ACE2 Knockout Engineered T Cells ) for Inducing Long-term Immunity in COVID-19 Patients
Year2021
CountryEgypt
Company sponsorMahmoud Ramadan mohamed Elkazzaz
Other ID(s)Novel Treatment for Covid-19

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 1E7 cells/kg in one cycle, a total of two cycles of treatment. Each cycle is divided into three administrations, with 20%, 30% and 50% respectively.
Donor type autologous
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route infusion
Dosage 1E7 cells/kg in one cycle, a total of two cycles of treatment. Each cycle is divided into three administrations, with 20%, 30% and 50% respectively. 2E7 cells/kg in one cycle, a total of two cycles of treatment. Each cycle is divided into three administrations, with 20%, 30% and 50% respectively.
Donor type autologous
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route infusion
Dosage 4E7 cells/kg in one cycle, a total of two cycles of treatment. Each cycle is divided into three administrations, with 20% infused in the first administration, 30% in the second, and the remaining 50% in the third.
Donor type autologous
Age Adult, Older_Adult

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