Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC2713
Trial ID NCT04923893
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Carvykti|Ciltacabtagene Autoleucel|Cilta-cel|JNJ-68284528
Location approved US, EU, UK, Japan, Australia, Canada
Generation2nd
PhasePhase3
Recruitment statusRecruiting
TitleA Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy (CARTITUDE-5)
Year2021
CountryUnited States
Company sponsorJanssen Research & Development, LLC
Other ID(s)CR109015|2021-001242-35|68284528MMY3004
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneBCMA-binding single domain; CD3ζ T-cell activation domain; 4-1BB costimulatory domain

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 7.5E6 cells/kg
Donor type Autologous
Pts 650
Age Adult, Older_Adult
Lymph depletion Yes
References DOI: 10.1182/blood-2021-146210

Relationship Graph

Overview of Knowledge Graph