Basic Information


GTO ID GTC2703
Trial ID NCT04911166
Disease Non-Small Cell Lung Cancer
Altered gene IL-12
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment Adv-IL12
Co-treatment Atezolizumab
PhasePhase1
Recruitment statusRecruiting
TitlePhase I Trial of Atezolizumab and Interleukin-12 Gene Therapy in Metastatic Non-Small Cell Lung Cancer With Progression on First-Line Immunotherapy With or Without Chemotherapy
Year2021
CountryUnited States
Company sponsorThe Methodist Hospital Research Institute
Other ID(s)PRO00026826
Vector information
Vectoradenovirus
ConstructAdv-IL12
Vector typeadenoviral vector
Transgene/Inserted geneinterleukin-12 (IL-12) gene

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage 1E11 vp, 3E11 vp, 5E11 vp
Pts 16
Age Adult, Older_Adult

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