Basic Information

Gene symbol ERBB2 Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description erb-b2 receptor tyrosine kinase 2

GTO ID GTC2699
Trial ID NCT04903080
Disease Brain Ependymoma
Altered gene HER2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment HER2 CAR-T cells
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleHER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma
Year2021
CountryUnited States
Company sponsorPediatric Brain Tumor Consortium
Other ID(s)PBTC-059

Clinical Result

Cohort 1
Administration route intravenous infusion
Pts 50
Age Child, Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph