Basic Information

Gene symbol CD276 Synonyms 4Ig-B7-H3, B7-H3, B7H3, B7RP-2 Type of gene protein-coding
Description CD276 molecule

GTO ID GTC2696
Trial ID NCT04897321
Disease Rhabdomyosarcoma | Neuroblastoma | Germ Cell Cancer | Ewing Sarcoma | Carcinoma | Adrenocortical Carcinoma | Osteosarcoma | Rhabdoid Tumor | Hepatoblastoma | Desmoplastic Small Round Cell Tumor | Melanoma | Peripheral Nerve Sheath Neoplasm | Childhood Soft Tissue Sarcoma | Clear Cell Sarcoma | Wilms' Tumor
Altered gene CD276
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment B7-H3 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleB7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
Year2021
CountryUnited States
Company sponsorSt. Jude Children's Research Hospital
Other ID(s)3CAR

Clinical Result

Cohort 1
Administration route intravenous infusion|central line
Donor type Autologous
Pts 32
Age Child, Adult
Lymph depletion Yes

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