Basic Information

Gene symbol CD274 Synonyms B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD274 molecule

GTO ID GTC2663
Trial ID NCT04847466
Disease Gastroesophageal Cancer | Head and Neck Squamous Cell Carcinoma
Altered gene PD-L1
Therapeutic/Target gene Target gene
TherapyCAR-NK cell
Treatment PD-L1 t-haNK
Co-treatment Pembrolizumab, N-803
PhasePhase2
Recruitment statusRecruiting
TitleImmunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancer
Year2021
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)10000096|000096-C

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2E9 cells
Pts 55
Age Adult, Older_Adult

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