Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC2642
Trial ID NCT04832724
Disease Age-Related Macular Degeneration
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment RGX-314
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleA Phase 2, Open-label Study to Explore the Pharmacodynamics of Two Doses in Two Formulations of RGX-314 Gene Therapy Administered Via Subretinal Delivery in Participants With Neovascular Age-related Macular Degeneration
Year2021
CountryUnited States
Company sponsorAbbVie
Other ID(s)RGX-314-2103
Vector information
Vectoradeno-associated virus
ConstructrAAV8-anti-VEGF protein
Vector typerecombinant adeno-associated virus serotype 8 (rAAV8) vector
Transgene/Inserted genea coding sequence for a soluble anti-VEGF protein

Clinical Result

Cohort 1
Administration route subretinal injection
Age Adult, Older_Adult
References PMID: 35017696

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