Basic Information

Gene symbol CD7 Synonyms GP40, LEU-9, TP41, Tp40 Type of gene protein-coding
Description CD7 molecule

GTO ID GTC2612
Trial ID NCT04785833
Disease T-Cell Acute Lymphoblastic Leukemia
Altered gene CD7
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD7 CAR-T cells
Generation2nd
Recruitment statusRecruiting
TitleCD7 CAR-T in the Treatment of CD7 Positive Refractory Relapsed Acute Leukemia
Year2021
CountryChina
Company sponsorPersonGen BioTherapeutics (Suzhou) Co., Ltd.
Other ID(s)PA-CART-3-17-001
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ|scFv-CD28-CD3ζ
Transgene/Inserted gene4-1BB co-stimulatory region; signal-transduction CD3z; (immunoreceptor tyrosine activation motif ITAM; FC hinge

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 20
Age Child, Adult, Older_Adult
Outcome Hematological and extramedullary remission were both achieved.
Adverse reactions grade 3 cytokine release syndrome and macrophage activation syndrome
References PMID: 35130959

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