Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2575
Trial ID NCT04718883
Disease Mantle Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Axi-Cel|Relma-cel|Axicabtagene Ciloleucel|JWCAR029|relmacabtagene autoleucel|Yescarta
Location approved China
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleCD19-targeted CAR T Cells for Relapsed and Refractory (R/R) Mantle Cell Lymphoma
Year2021
CountryChina
Company sponsorShanghai Ming Ju Biotechnology Co., Ltd.
Other ID(s)JWCAR029-005

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E8 cells
Pts 66
Age Adult, Older_Adult
Outcome 23/42(CR); 4/42(PR). Best ORR was 78.57% and best CRR was 66.67%.
Adverse reactions 31/56(CRS); 6/56(neurotoxicities); 27/56(infections); 47/56(prolonged cytopenia); 8/56(death)
References DOI: 10.1182/blood-2023-178430

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