Basic Information

Gene symbol GPC3 Synonyms DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 Type of gene protein-coding
Description glypican 3

GTO ID GTC2571
Trial ID NCT04715191
Disease Liver Cancer | Liposarcoma | Malignant Rhabdoid Tumor | Rhabdomyosarcoma | Wilms' Tumor | Yolk Sac Tumor
Altered gene GPC3
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment 15.21.GPC3 CAR-T cells
PhasePhase1
Recruitment statusNot Recruiting
TitleInterleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors
Year2021
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)CARE
Vector information
Vectorretrovirus
Additional featureIL15, IL21, iCasp9

Clinical Result

Cohort 1
Administration route None
Dosage 1E8 cells/m^2, 3E8 cells/m^2, 1E9 cells/m^2
Donor type Autologous
Pts 24
Age Child, Adult
Lymph depletion Yes

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