Basic Information

Gene symbol CD276 Synonyms 4Ig-B7-H3, B7-H3, B7H3, B7RP-2 Type of gene protein-coding
Description CD276 molecule

GTO ID GTC2539
Trial ID NCT04670068
Disease Epithelial Ovarian Cancer
Altered gene CD276
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment B7-H3 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitlePhase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian
Year2020
CountryUnited States
Company sponsorUNC Lineberger Comprehensive Cancer Center
Other ID(s)LCCC1818-ATL

Clinical Result

Cohort 1
Administration route None
Dosage 7.5E7 cells/infusion, 2E8 cells/infusion
Donor type Autologous
Pts 21
Age Adult, Older_Adult
Lymph depletion Yes

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