Basic Information

Gene symbol S Synonyms E2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description spike glycoprotein


GTO ID GTC2537
Trial ID NCT04668339
Disease COVID-19 | Coronavirus Infectious Disease
Altered gene VEEV|S
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment ARCT-021
PhasePhase2
Recruitment statusTerminated
TitleA Phase 2 Randomized, Observer-Blind, Placebo-Controlled Study to Assess the Safety, Reactogenicity, and Immunogenicity of the SARS CoV-2 Vaccine ARCT-021 in Healthy Adult Participants
Year2021
CountryUnited States|Singapore
Company sponsorArcturus Therapeutics, Inc.
Other ID(s)ARCT-021-04
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort1: Younger Adult Participants_ARCT-021_Placebo_ARCT-021/Placebo
Administration route None
Dosage ARCT-021, one dose, on Day 0, Placebo (saline), one dose, on Day 28; on Day 208 either one dose of ARCT-021 or one dose of placebo
Age Adult, Older_Adult
Cohort2: Younger Adult Participants_ARCT-021_ARCT-021_ARCT-021/Placebo
Administration route None
Dosage ARCT-021, one dose, on Day 0, second dose on Day 28, on Day 208 either one dose of ARCT-021 or one dose of placebo
Age Adult, Older_Adult
Cohort3: Younger Adult Participants_Placebo_Placebo_Placebo
Administration route None
Dosage Placebo (Saline), one dose on Day 0, one dose on Day 28, and one dose on Day 208
Age Adult, Older_Adult
Cohort4: Older Adult Participants_ARCT-021_Placebo_ARCT-021/Placebo
Administration route None
Dosage ARCT-021, one dose, on Day 0, Placebo (saline), one dose, on Day 28; on Day 208 either one dose of ARCT-021 or one dose of placebo
Age Adult, Older_Adult
Cohort5: Older Adult Participants_ARCT-021_ARCT-021_ARCT-021/Placebo
Administration route None
Dosage ARCT-021, one dose, on Day 0, second dose on Day 28, on Day 208 either one dose of ARCT-021 or one dose of placebo
Age Adult, Older_Adult
Cohort6: Older Adult Participants_Placebo_Placebo_Placebo
Administration route None
Dosage Placebo (Saline), one dose on Day 0, one dose on Day 28, and one dose on Day 208
Age Adult, Older_Adult

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