Basic Information

Gene symbol ITIH4 Synonyms GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120 Type of gene protein-coding
Description inter-alpha-trypsin inhibitor heavy chain 4

GTO ID GTC2516
Trial ID NCT04648046
Disease HIV Infection
Altered gene gp120
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment LVgp 120 duoCAR-T cells
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleCAR-T Cells for HIV Infection
Year2020
CountryUnited States
Company sponsorSteven Deeks
Other ID(s)20-31976
Vector information
Vectorlentivirus

Clinical Result

Cohort1: dose level 1_no lymphodepleting
Administration route None
Dosage 3E5 cells/kg, single infusion
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion No
Cohort2: dose level 1_lymphodepletion
Administration route None
Dosage 3E5 cells/kg, single infusion
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort3: dose level 2_lymphodepletion
Administration route None
Dosage 1E6 cells/kg, single infusion
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes

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